Article
A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes in Magee2 Null Mice.
Molecular biology and evolution - 9 Dec 2021
Szpak Michał, Collins Stephan C, Li Yan, Liu Xiao, Ayub Qasim, Fischer Marie-Christine, Vancollie Valerie E, Lelliott Christopher J, Xue Yali, Yalcin Binnaz, Yang Huanming, Tyler-Smith Chris
Abstract excerpt
A nonsense allele at rs1343879 in human MAGEE2 on chromosome X has previously been reported as a strong candidate for positive selection in East Asia. This premature stop codon causing ∼80% protein truncation is characterized by a striking geographical pattern of high population differentiation: common in Asia and the Americas (up to 84% in the 1000 Genomes Project East Asians) but rare elsewhere. Here, we...
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