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Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway

15 Apr 2008

Abstract excerpt

Glypican-3 (gpc3) is the gene responsible for Simpson-Golabi-Behmel overgrowth syndrome. Previously, we have shown that GPC3 is overexpressed in hepatocellular carcinoma (HCC). In this study, we demonstrated the mechanisms for GPC3-mediated oncogenesis. Firstly, GPC3 overexpression in NIH3T3 cells gave to cancer cell phenotypes including growing in serum-free medium and forming colonies in soft agar, or on the...

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PMID: 18413366
DOI: 10.1093/carcin/bgn091

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