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Article

The Simpson–Golabi–Behmel syndrome causative Glypican‐3, binds to and inhibits the dipeptidyl peptidase activity of CD26

1 Jun 2007

Abstract excerpt

Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked condition shown to be the result of deletions of the glypican-3 (GPC3) gene. GPC3 is a proteoglycan localized to the cell membrane via a glycosylphosphatidyl-inositol (GPI) anchor. To further elucidate the GPC3 function(s), we have screened various cell lines for proteins that interact with GPC3, resulting in the isolation of a 115 kDa protein, identified as...

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Share to Peptidase Inhibition and Analysis
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Identifiers

PMID: 17549790
DOI: 10.1002/pmic.200600654

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