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Article

Silencing of the glypican-3 gene affects the biological behavior of human hepatocellular carcinoma cells

26 Sept 2014

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world. The gene glypican-3 (GPC3) is reported to be a potential therapeutic target for HCC. In this study, we use RNA interference with lentiviral vectors to explore the effect of GPC3 silencing on the biological behavior of HCC cells and the potential role of the GPC3 protein in the activation of epithelial-mesenchymal transition...

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Identifiers

PMID: 25270552
DOI: 10.3892/mmr.2014.2600

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