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Article

The clf2 gene has an epigenetic role in the multifactorial etiology of cleft lip and palate in the A/WySn mouse strain.

Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2011

Plamondon Jenna A, Harris Muriel J, Mager Dixie L, Gagnier Liane, Juriloff Diana M

Abstract excerpt

BACKGROUND: The A/WySn mouse strain with 15 to 20% penetrance of cleft lip and palate (CLP) is an animal model for human multifactorial CLP. The CLP is due to two unlinked genes that interact epistatically, Wnt9b(clf1) and clf2, plus a maternal effect. The Wnt9b(clf1) mutation is an IAP transposon insertion. The clf2 gene, with unknown function, was located in a 13.6 Mb region of chromosome 13 containing 145...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21384535
DOI: 10.1002/bdra.20788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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