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Article

Distinct sets of genetic alterations in melanoma.

The New England journal of medicine - 17 Nov 2005

Curtin John A, Fridlyand Jane, Kageshita Toshiro, Patel Hetal N, Busam Klaus J, Kutzner Heinz, Cho Kwang-Hyun, Aiba Setsuya, Bröcker Eva-Bettina, LeBoit Philip E, Pinkel Dan, Bastian Boris C

Abstract excerpt

BACKGROUND: Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposure is complex. We hypothesized that the clinical heterogeneity is explained by genetically distinct types of melanoma with different susceptibility to ultraviolet li...

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Source

Identifiers

PMID: 16291983
DOI: 10.1056/NEJMoa050092

Genes

BRAF
CCND1
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16291983-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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