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Article

Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas.

Archives of dermatology - 1 Jul 1995

Spencer J M, Kahn S M, Jiang W, DeLeo V A, Weinstein I B

Abstract excerpt

UNLABELLED: BACKGROUND/DESIGN: The clonal theory of cancer predicts that transformed cells within a given tumor are derived from a single initiated precursor. Advancement of this precursor through various stages of tumor development occurs with the further accumulation of selective genetic and epigenetic lesions. Mammalian ras genes are important constituents of mitogenic signaling pathways, and when activated,...

Topics

Base Sequence
Carcinoma, Squamous Cell
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Keratosis
Molecular Sequence Data
Mutation
Precancerous Conditions
Skin Neoplasms
Transcriptional Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ultraviolet Rays

Source

Identifiers

PMID: 7611795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7611795-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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