Activation of GATA binding protein 6 ( <i>GATA6</i> ) sustains oncogenic lineage-survival in esophageal adenocarcinoma

Abstract excerpt

Gene amplification is a tumor-specific event during malignant transformation. Recent studies have proposed a lineage-dependency (addiction) model of human cancer whereby amplification of certain lineage transcription factors predisposes a survival mechanism in tumor cells. These tumor cells are derived from tissues where the lineage factors play essential developmental and maintenance roles. Here, we show that...

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