Article
The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway.
Developmental biology - 1 Aug 2002
Merlo Giorgio R, Paleari Laura, Mantero Stefano, Zerega Barbara, Adamska Maja, Rinkwitz Silke, Bober Eva, Levi Giovanni
Abstract excerpt
In the mouse embryo, Dlx5 is expressed in the otic placode and vesicle, and later in the semicircular canals of the inner ear. In mice homozygous for a null Dlx5/LacZ allele, a severe dysmorphogenesis of the vestibular region is observed, characterized by the absence of semicircular canals and the shortening of the endolymphatic duct. Minor defects are observed in the cochlea, although Dlx5 is not expressed in...
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