Article
GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.
BMC genetics - 10 Apr 2008
Anderson Michael G, Nair K Saidas, Amonoo Leslie A, Mehalow Adrienne, Trantow Colleen M, Masli Sharmila, John Simon W M
Abstract excerpt
BACKGROUND: The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris disease and abnormalities of the immunosuppressive ocular microenvironment. RESULTS: We find...
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