Article
Effect of osteopontin alleles on beta-glucan-induced granuloma formation in the mouse liver.
The American journal of pathology - 1 Feb 2004
Tanaka Kumiko, Morimoto Junko, Kon Shigeyuki, Kimura Chiemi, Inobe Manabu, Diao Hongyan, Hirschfeld Gregor, Weiss Johannes M, Uede Toshimitsu
Abstract excerpt
The granuloma formation is a host defense response against persistent irritants. Osteopontin is centrally involved in the formation of granulomas. Three osteopontin alleles, designated a, b, and c, have been found in mice. Here we used a murine model of zymosan (beta-glucan)-induced granuloma formation in the liver to determine possible functional differences between the osteopontin alleles in cell-mediated...
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