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Article

Gating of the ATP-sensitive K+ channel by a pore-lining phenylalanine residue.

Biochimica et biophysica acta - 1 Jan 2007

Rojas Asheebo, Wu Jianping, Wang Runping, Jiang Chun

Abstract excerpt

ATP-sensitive K(+) (K(ATP)) channels are gated by intracellular ATP, proton and phospholipids. The pore-forming Kir6.2 subunit has all essential machineries for channel gating by these ligands. It is known that channel gating involves the inner helix bundle of crossing in which a phenylalanine residue (Phe168) is found in the TM2 at the narrowest region of the ion-conduction pathway in the Kir6.2. Here we present...

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Identifiers

PMID: 16970907
DOI: 10.1016/j.bbamem.2006.06.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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