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Article

d3-GHR genotype does not explain heterogeneity in GH responsiveness in hypopituitary adults.

Clinical endocrinology - 1 Jun 2010

Moyes V J, Walker D M, Owusu-Antwi S, Maher K T, Metherell L, Akker S A, Monson J P, Clark A J L, Drake W M

Abstract excerpt

OBJECTIVE: Heterogeneity in growth hormone (GH) responsiveness in adult hypopituitary patients receiving recombinant human GH (rhGH) is poorly understood; doses vary up to fourfold between individuals. Deletion of exon 3 in the GH receptor (d3-GHR) has been linked to enhanced rhGH responsiveness in children. We investigated the role of the d3-GHR polymorphism in determining adult rhGH responsiveness. METHODS: One...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20039885
DOI: 10.1111/j.1365-2265.2009.03768.x

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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