Article
Association of interferon regulatory factor-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2008
Sermasathanasawadi Radsamee, Kato Naoya, Muroyama Ryosuke, Dharel Narayan, Shao Run-Xuan, Chang Jin-Hai, Li Chang-Zheng, Kawabe Takao, Omata Masao
Abstract excerpt
BACKGROUND AND AIMS: Interferon (IFN) regulatory factor 7 (IRF-7) has been shown to play an essential role in the transcriptional activation of virus-inducible cellular genes, especially IFN genes. Polymorphisms of the IRF-7 gene may probably affect both the quality and the quantity of IRF-7. We investigated the role of IRF-7 polymorphisms in Japanese patients with chronic hepatitis C virus (HCV) infection....
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