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Article

NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas.

The American journal of pathology - 1 Jul 2011

Moreira Frederico, Kiehl Tim-Rasmus, So Kelvin, Ajeawung Norbert F, Honculada Carmelita, Gould Peter, Pieper Russell O, Kamnasaran Deepak

Abstract excerpt

Malignant astrocytomas, the most common primary brain tumors, are predominantly fatal. Improved treatments will require a better understanding of the biological features of high-grade astrocytomas. To better understand the role of neuronal PAS 3 (NPAS3) in diseases in human beings, it was investigated as a candidate for astrocytomagenesis based on the presence of aberrant protein expression in greater than 70% of...

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Identifiers

PMID: 21703424
DOI: 10.1016/j.ajpath.2011.03.044
PMCID: PMC3123785

Genes

NPAS3

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