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Article

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas

4 Apr 2011

Abstract excerpt

Glioblastoma Multiforme (GBM), the most common and lethal primary human brain tumor, exhibits multiple molecular aberrations. We report that loss of the transcription factor GATA4, a negative regulator of normal astrocyte proliferation, is a driver in glioma formation and fulfills the hallmarks of a tumor suppressor gene (TSG). Although GATA4 was expressed in normal brain, loss of GATA4 was observed in 94/163 GBM...

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PMID: 21464220
DOI: 10.1084/jem.20102099

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