Article
High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours.
British journal of cancer - 15 Jul 2002
Hu J, Pang J C-S, Tong C Y-K, Lau B, Yin X-L, Poon W-S, Jiang C-C, Zhou L-F, Ng H-K
Abstract excerpt
Diffusely infiltrative astrocytic tumours are the most common neoplasms in the human brain. To localise putative tumour suppressor loci that are involved in low-grade astrocytomas, we performed high-resolution genome-wide allelotype analysis on 17 fibrillary astrocytomas. Non-random allelic losses were identified on chromosomal arms 10p (29%), 10q (29%), 14q (35%), 17p (53%), and 19q (29%), with their respective...
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