Article
Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.
Biochemical and biophysical research communications - 23 Aug 2013
Ochiai Natsuki, Nishizuka Makoto, Miyamoto Tomomi, Miyoshi Ichiro, Ikawa Masahito, Osada Shigehiro, Imagawa Masayoshi
Abstract excerpt
In previous studies, we identified a novel gene, factor for adipocyte differentiation 24 (fad24), which plays an important role during the early stages of adipogenesis in mouse 3T3-L1 cells. Moreover, overexpression of fad24 increased the number of smaller adipocytes in white adipose tissue and improved glucose metabolic activity in mice, thus indicating that fad24 functions as a regulator of adipogenesis in...
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