Article
Regulation of Gic2 localization and function by phosphatidylinositol 4,5-bisphosphate during the establishment of cell polarity in budding yeast.
The Journal of biological chemistry - 23 May 2008
Orlando Kelly, Zhang Jian, Zhang Xiaoyu, Yue Peng, Chiang Teresa, Bi Erfei, Guo Wei
Abstract excerpt
Establishment of cell polarity is important for a wide range of biological processes, from asymmetric cell growth in budding yeast to neurite formation in neurons. In the yeast Saccharomyces cerevisiae, the small GTPase Cdc42 controls polarized actin organization and exocytosis toward the bud. Gic2, a Cdc42 effector, is targeted to the bud tip and plays an important role in early bud formation. The GTP-bound...
Topics
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- Cell Membrane
- Cell Polarity
- Gene Expression Regulation, Fungal
- Mutation
- Phosphatidylinositol 4,5-Diphosphate
- Phosphotransferases
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Binding
- Protein Transport
- Saccharomyces cerevisiae