Article
Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson's disease in two European populations.
Journal of negative results in biomedicine - 14 Dec 2005
Schlitter Anna Melissa, Kurz Martin, Larsen Jan P, Woitalla Dirk, Mueller Thomas, Epplen Joerg T, Dekomien Gabriele
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recently, mutations in the PINK1 (PARK6) gene were shown to rarely cause autosomal-recessively transmitted, early-onset parkinsonism. In order to evaluate whether PINK1 contributes to the risk of common late-onset PD we analysed PINK1 sequence variations. A German (85 patients) and a Norwegian cohort (90 patients) suffering...
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