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Article

Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

Cancer research - 15 Mar 2006

Hacker Elke, Muller H Konrad, Irwin Nicole, Gabrielli Brian, Lincoln Douglas, Pavey Sandra, Powell Marianne Broome, Malumbres Marcos, Barbacid Mariano, Hayward Nicholas, Walker Graeme

Abstract excerpt

Human melanoma susceptibility is often characterized by germ-line inactivating CDKN2A (INK4A/ARF) mutations, or mutations that activate CDK4 by preventing its binding to and inhibition by INK4A. We have previously shown that a single neonatal UV radiation (UVR) dose delivered to mice that carry melanocyte-specific activation of Hras (TPras) increases melanoma penetrance from 0% to 57%. Here, we report that...

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Share to Cocarcinogenesis
Share to Cyclin-Dependent Kinase 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, ras

Share to Melanoma, Experimental

Share to Mice, Transgenic

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Source

Identifiers

PMID: 16540642
DOI: 10.1158/0008-5472.CAN-05-3196

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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