Article
Selected polymorphisms of DNA repair genes and risk of pancreatic cancer.
Cancer detection and prevention - 1 Jan 2006
Jiao Li, Bondy Melissa L, Hassan Manal M, Wolff Robert A, Evans Douglas B, Abbruzzese James L, Li Donghui
Abstract excerpt
BACKGROUND: Genetic variants of DNA repair genes may contribute to pancreatic carcinogenesis. O(6)-methylguanine-DNA methyltransferase (MGMT) is the major protein that removes alkylating DNA adducts, and apurinic/apyrimidinic endonuclease 1 (APE1) and X-ray repair cross-complementing group 1 (XRCC1) play important roles in the base excision repair pathway. METHODS: We investigated the association between...
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