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Article

XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.

Carcinogenesis - 1 Jun 2007

Liu Geoffrey, Zhou Wei, Yeap Beow Y, Su Li, Wain John C, Poneros John M, Nishioka Norman S, Lynch Thomas J, Christiani David C

Abstract excerpt

DNA damage is important in the pathogenesis of esophageal adenocarcinoma (EA). Polymorphic variants in DNA repair genes may be modifiers of the risk of EA through their role in altering human host response to gastroesophageal acid reflux, a well-described risk factor for EA. We studied the role of genetic polymorphisms of two key DNA repair genes, xeroderma pigmentosum group D (XPD) (Asp312Asn and Lys751Gln) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17264068
DOI: 10.1093/carcin/bgm020

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.PMID 17264068Read ↗

Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinomaSemantic proximity Read ↗

XPD Lys751Gln polymorphism and esophageal cancer risk: a meta-analysis involving 2288 cases and 4096 controls.Semantic proximity Read ↗

XPD Lys751Gln polymorphisms and the risk of esophageal cancer: an updated meta-analysis.Semantic proximity Read ↗

Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk.Semantic proximity Read ↗

XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case-control studies.Semantic proximity Read ↗

The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden.Semantic proximity Read ↗

[DNA repair gene xeroderma pigmentosum group D 751 polymorphism and the risk on esophageal cancer: a meta-analysis].Semantic proximity Read ↗

Xeroderma pigmentosum group D polymorphisms and esophageal cancer susceptibility: a meta-analysis based on case-control studies.Semantic proximity Read ↗

The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis.Semantic proximity Read ↗

Association between the XPD/ERCC2 Lys751Gln polymorphism and risk of cancer: evidence from 224 case-control studies.Semantic proximity Read ↗

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer RiskSemantic proximity Read ↗

XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review.Semantic proximity Read ↗

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