Article
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2001
Sansig G, Bushell T J, Clarke V R, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor P J, Kuhn R, Knoepfel T, Schroeder M, Hampson D R, Collett V J, Zhang C, Duvoisin R M, Collingridge G L, van Der Putten H
Abstract excerpt
To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7(-/-)). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals aged 12 weeks and older, subthreshold doses of these drugs induced seizures in mGluR7(-/-),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.