Article
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration.
Human molecular genetics - 1 Jun 2005
Zareparsi Sepideh, Buraczynska Monika, Branham Kari E H, Shah Sapna, Eng Donna, Li Mingyao, Pawar Hemant, Yashar Beverly M, Moroi Sayoko E, Lichter Paul R, Petty Howard R, Richards Julia E, Abecasis Gonçalo R, Elner Victor M, Swaroop Anand
Abstract excerpt
Age-related macular degeneration (AMD) is a genetically heterogeneous disease that leads to progressive and irreversible vision loss among the elderly. Inflammation, oxidative damage, cholesterol metabolism and/or impaired function of retinal pigment epithelium (RPE) have been implicated in AMD pathogenesis. We examined toll-like receptor 4 (TLR4) as a candidate gene for AMD susceptibility because: (i) the TLR4...
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