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Article

Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis

27 Mar 2008

Abstract excerpt

OBJECTIVE: In rheumatoid arthritis (RA), telomeres of lymphoid and myeloid cells are age-inappropriately shortened, suggesting excessive turnover of hematopoietic precursor cells (HPCs). The purpose of this study was to examine the functional competence (proliferative capacity, maintenance of telomeric reserve) of CD34+ HPCs in RA. METHODS: Frequencies of peripheral blood CD34+,CD45+ HPCs from 63 rheumatoid...

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Share to Hematopoietic Stem Cell Transplantation
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Share to Telomeres, Telomerase, and Senescence

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PMID: 18383391
DOI: 10.1002/art.23287

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