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Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1 Mar 1996

Abstract excerpt

The loss of telomeric DNA may serve as a mitotic clock which signals cell senescence and exit from cell cycle. Telomerase, and enzyme which synthesizes telomeric repeats de novo, is required to maintain telomere lengths. In humans, significant telomerase activity has been found in cells with essentially unlimited replicative potential such as reproductive cells in ovaries and testes, immortal cell lines and...

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PMID: 8991544
DOI: 10.1002/stem.140239

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