Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation.

doi:10.1002/art.1780351209

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Article

Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation.

Arthritis and rheumatism - 1 Dec 1992

Thomas R, McIlraith M, Davis L S, Lipsky P E

Abstract excerpt

OBJECTIVE: To delineate the phenotype and function of synovial T cells in rheumatoid arthritis (RA). METHODS: T cells from normal subjects or from RA peripheral blood (PB), synovial fluid (SF), or synovial tissue (ST) were analyzed phenotypically and functionally. RESULTS: RA SF and ST T cells were found to be markedly enriched in CD45RAdim, CD45RO+, CD45RBdim mature memory cells, whereas in the PB, CD45RAbright...

Topics

Adult
Aged
Arthritis, Rheumatoid
B-Lymphocytes
Cell Differentiation
Cells, Cultured
Female
Humans
Immunoglobulins
Immunologic Memory
Interleukin-2
Leukocyte Common Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mitogens

Mitomycin

Phenotype

Synovial Fluid

Synovial Membrane

Source

Open in PubMed

Identifiers

PMID: 1472123
DOI: 10.1002/art.1780351209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1472123-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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