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Article

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

11 Oct 1994

Abstract excerpt

The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of telomeric DNA from the ends of human chromosomes with each somatic cell division eventually reaches a critical point that triggers cellular senescence. We now show that candidate human stem cells with a CD34+CD38lo phenotype that were purified from adult bone...

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PMID: 7937905
DOI: 10.1073/pnas.91.21.9857

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