Article
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Schönland Stefan O, Lopez Consuelo, Widmann Thomas, Zimmer Julia, Bryl Ewa, Goronzy Jörg J, Weyand Cornelia M
Abstract excerpt
In rheumatoid arthritis, peripheral blood T cells have age-inappropriate telomeric erosion. We examined whether HLA-DRB1*04 alleles, the major susceptibility genes for this disease, confer risk for T cell senescence. In healthy individuals, HLA-DRB1*04 alleles were associated with excessive loss of telomeres in CD4+ T cells. Accelerated telomeric erosion occurred during the first two decades of life and was...
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