Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomerase insufficiency in rheumatoid arthritis

2 Mar 2009

Abstract excerpt

In rheumatoid arthritis (RA), chronically stimulated T lymphocytes sustain tissue-destructive joint inflammation. Both naïve and memory T cells in RA are prematurely aged with accelerated loss of telomeres suggesting excessive proliferative pressure or inadequate telomeric maintenance. Upon stimulation, RA naïve CD4 T cells are defective in up-regulating telomerase activity (P < 0.0001) due to insufficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immunotherapy and Immune Responses
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19255426
DOI: 10.1073/pnas.0811332106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomerase insufficiency in rheumatoid arthritisPMID 19255426Read ↗

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritisSemantic proximity Read ↗

TCR repertoire analysis reveals effector memory T cells differentiation into Th17 cells in rheumatoid arthritisSemantic proximity Read ↗

Defective T-Cell Apoptosis and T-Regulatory Cell Dysfunction in Rheumatoid ArthritisSemantic proximity Read ↗

Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritisSemantic proximity Read ↗

Hyperexpanded CD4 <sup>+</sup> T cell clones in rheumatoid arthritis show attenuated senescence and accumulate in afflicted jointsSemantic proximity Read ↗

Immune Aging in Rheumatoid ArthritisSemantic proximity Read ↗

An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.Semantic proximity Read ↗

Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and SurvivalSemantic proximity Read ↗

Telomerase Therapeutics for Degenerative DiseasesSemantic proximity Read ↗

Telomerase deficiency reflects age-associated changes in CD4+ T cellsSemantic proximity Read ↗

The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor SignalingSemantic proximity Read ↗

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.