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Article

T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease.

Arthritis and rheumatism - 1 Apr 2008

Boin Francesco, De Fanis Umberto, Bartlett Susan J, Wigley Fredrick M, Rosen Antony, Casolaro Vincenzo

Abstract excerpt

OBJECTIVE: Lung involvement is the leading cause of morbidity and mortality in systemic sclerosis (SSc; scleroderma), and interstitial lung disease (ILD) is the most common pulmonary manifestation. An abnormal profibrotic Th2/Tc2-polarized T cell response is postulated to mediate tissue damage and fibrosis. The aim of this study was to investigate whether a polarized T cell phenotype in SSc is associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18383361
DOI: 10.1002/art.23406
PMCID: PMC2662772

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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