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Article

Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome.

Journal of autoimmunity - 1 Dec 2024

Miedema Jelle R, de Jong Lieke J, van Uden Denise, Bergen Ingrid M, Kool Mirjam, Broos Caroline E, Kahlmann Vivienne, Wijsenbeek Marlies S, Hendriks Rudi W, Corneth Odilia B J

Abstract excerpt

RATIONALE: Disease course in sarcoidosis is highly variable. Bronchoalveolar lavage fluid and mediastinal lymph nodes show accumulation of activated T cells with a T-helper (Th)17.1 signature, which correlates with non-resolving sarcoidosis. We hypothesize that the peripheral blood (PB) T cell phenotype may correlate with outcome. OBJECTIVES: To compare frequencies, phenotypes and function of circulating T cell...

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Source

Identifiers

PMID: 37863732
DOI: 10.1016/j.jaut.2023.103120

Genes

CD4
CD69
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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