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Article

Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function.

The Journal of cell biology - 17 Jan 2005

Martin Adam C, Xu Xiao-Ping, Rouiller Isabelle, Kaksonen Marko, Sun Yidi, Belmont Lisa, Volkmann Niels, Hanein Dorit, Welch Matthew, Drubin David G

Abstract excerpt

Contributions of actin-related proteins (Arp) 2 and 3 nucleotide state to Arp2/3 complex function were tested using nucleotide-binding pocket (NBP) mutants in Saccharomyces cerevisiae. ATP binding by Arp2 and Arp3 was required for full Arp2/3 complex nucleation activity in vitro. Analysis of actin dynamics and endocytosis in mutants demonstrated that nucleotide-bound Arp3 is particularly important for Arp2/3...

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Identifiers

PMID: 15657399
DOI: 10.1083/jcb.200408177
PMCID: PMC2171590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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