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Article

Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation.

Nature cell biology - 1 Aug 2006

Martin Adam C, Welch Matthew D, Drubin David G

Abstract excerpt

The Arp2/3 complex, which is crucial for actin-based motility, nucleates actin filaments and organizes them into y-branched networks. The Arp2 subunit has been shown to hydrolyse ATP, but the functional importance of Arp2/3 ATP hydrolysis is not known. Here, we analysed an Arp2 mutant in Saccharomyces cerevisiae that is defective in ATP hydrolysis. Arp2 ATP hydrolysis and Arp2/3-dependent actin nucleation occur...

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Source

Identifiers

PMID: 16862144
DOI: 10.1038/ncb1443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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