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Article

Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment.

Social cognitive and affective neuroscience - 1 Jun 2012

Troisi Alfonso, Frazzetto Giovanni, Carola Valeria, Di Lorenzo Giorgio, Coviello Mariangela, Siracusano Alberto, Gross Cornelius

Abstract excerpt

There is evidence that both early experience and genetic variation play a role in influencing sensitivity to social rejection. In this study, we aimed at ascertaining if the A118G polymorphism of the μ-opioid receptor gene (OPRM1) moderates the impact of early maternal care on fearful attachment, a personality trait strongly related to rejection sensitivity. In 112 psychiatric patients, early maternal care and...

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Source

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Identifiers

PMID: 21742765
DOI: 10.1093/scan/nsr037
PMCID: PMC3375889

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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