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Article

Variation in the μ-opioid receptor gene (OPRM1) and experiences of felt security in response to a romantic partner's quarrelsome behavior.

Molecular psychiatry - 1 Aug 2021

Tchalova Kristina, Sadikaj Gentiana, Moskowitz D S, Zuroff David C, Bartz Jennifer A

Abstract excerpt

Research suggests that endogenous opioids play a key role in the creation and maintenance of attachment bonds. Opioids acting at the μ-opioid receptor mediate reward and analgesia and are thus thought to underlie feelings of comfort and warmth experienced in the presence of close others. Disruption of μ-opioidergic activity increases separation distress in animals, suggesting that low opioid states may contribute...

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Identifiers

PMID: 31772303
DOI: 10.1038/s41380-019-0600-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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