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Article

Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment.

Translational psychiatry - 5 Apr 2024

Tchalova K, Lydon J E, Atkinson L, Fleming A S, Kennedy J, Lecompte V, Meaney M J, Moss E, O'Donnell K A, O'Donnell K J, Silveira P P, Sokolowski M B, Steiner M, Bartz J A

Abstract excerpt

The endogenous opioid system is thought to play an important role in mother-infant attachment. In infant rhesus macaques, variation in the μ-opioid receptor gene (OPRM1) is related to differences in attachment behavior that emerges following repeated separation from the mother; specifically, infants carrying at least one copy of the minor G allele of the OPRM1 C77G polymorphism show heightened and more persistent...

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PMID: 38580654
DOI: 10.1038/s41398-024-02888-x
PMCID: PMC10997775

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