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Article

Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents.

Antimicrobial agents and chemotherapy - 1 Jun 2008

Miller Keith, O'Neill Alexander J, Wilcox Mark H, Ingham Eileen, Chopra Ian

Abstract excerpt

The development of resistance to linezolid (LZD) in gram-positive bacteria depends on the mutation of a single 23S rRNA gene, followed by homologous recombination and gene conversion of the other alleles. We sought to inhibit this process in Staphylococcus aureus using a range of antibacterial agents, including some that suppress recombination. A model for the rapid selection of LZD resistance was developed which...

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Identifiers

PMID: 18378719
DOI: 10.1128/AAC.01302-07
PMCID: PMC2415777

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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