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Article

In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 May 2003

Firsov Alexander A, Vostrov Sergey N, Lubenko Irene Y, Drlica Karl, Portnoy Yury A, Zinner Stephen H

Abstract excerpt

To study the hypothesis of the mutant selection window (MSW) in a pharmacodynamic context, the susceptibility of a clinical isolate of methicillin-resistant Staphylococcus aureus exposed to moxifloxacin (MOX), gatifloxacin (GAT), levofloxacin (LEV), and ciprofloxacin (CIP) was tested daily by using an in vitro dynamic model that simulates human pharmacokinetics. A series of monoexponential pharmacokinetic...

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Identifiers

PMID: 12709329
DOI: 10.1128/AAC.47.5.1604-1613.2003
PMCID: PMC153314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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