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Article

Predicting bacterial resistance using the time inside the mutant selection window: possibilities and limitations.

International journal of antimicrobial agents - 1 Oct 2014

Firsov Alexander A, Portnoy Yury A, Strukova Elena N, Shlykova Darya S, Zinner Stephen H

Abstract excerpt

The time inside the mutant selection window (TMSW) has been shown to be less predictive of selection of fluoroquinolone-resistant bacteria than the ratio of the area under the concentration-time curve to minimum inhibitory concentration (AUC/MIC). To explore the different predictive powers of TMSW and AUC/MIC, enrichment of ciprofloxacin-resistant mutants of four Escherichia coli strains was studied in an in...

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Identifiers

PMID: 25218155
DOI: 10.1016/j.ijantimicag.2014.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Predicting bacterial resistance using the time inside the mutant selection window: possibilities and limitations.PMID 25218155Read ↗

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