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Article

Time inside the mutant selection window as a predictor of staphylococcal resistance to linezolid.

The Journal of antibiotics - 1 May 2018

Alieva Kamilla N, Strukova Elena N, Golikova Maria V, Portnoy Yury A, Zinner Stephen H, Firsov Alexander A

Abstract excerpt

To explore if the time inside the mutant selection window (TMSW) is a reliable predictor of emergence of bacterial resistance to linezolid, mixed inocula of each of three methicillin-resistant Staphylococcus aureus strains (MIC of linezolid 2 μg ml-1) and their previously selected resistant mutants (MIC 8 μg ml-1) were exposed to linezolid pharmacokinetics using an in vitro dynamic model. In five-day treatments...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29348530
DOI: 10.1038/s41429-017-0016-9

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