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Article

Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6.

Development (Cambridge, England) - 1 Jul 2003

Scardigli Raffaella, Bäumer Nicole, Gruss Peter, Guillemot François, Le Roux Isabelle

Abstract excerpt

Expression of the proneural gene Neurogenin2 is controlled by several enhancer elements, with the E1 element active in restricted progenitor domains in the embryonic spinal cord and telencephalon that express the homeodomain protein Pax6. We show that Pax6 function is both required and sufficient to activate this enhancer, and we identify one evolutionary conserved sequence in the E1 element with high similarity...

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Source

Identifiers

PMID: 12783797
DOI: 10.1242/dev.00539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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