Article
Coupling of cell migration with neurogenesis by proneural bHLH factors.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006
Ge Weihong, He Fei, Kim Kevin J, Blanchi Bruno, Coskun Volkan, Nguyen Laurent, Wu Xiangbing, Zhao Jing, Heng Julian Ik-Tsen, Martinowich Keri, Tao Jifang, Wu Hao, Castro Diogo, Sobeih Magdi M, Corfas Gabriel, Gleeson Joseph G, Greenberg Michael E, Guillemot Francois, Sun Yi E
Abstract excerpt
After cell birth, almost all neurons in the mammalian central nervous system migrate. It is unclear whether and how cell migration is coupled with neurogenesis. Here we report that proneural basic helix-loop-helix (bHLH) transcription factors not only initiate neuronal differentiation but also potentiate cell migration. Mechanistically, proneural bHLH factors regulate the expression of genes critically involved...
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