Article
No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.
Molecular genetics and metabolism - 1 Apr 2007
Müller Timo Dirk, Reichwald Kathrin, Wermter Anne-Kathrin, Brönner Günter, Nguyen Thuy Trang, Friedel Susann, Koberwitz Kerstin, Engeli Stefan, Lichtner Peter, Meitinger Thomas, Schäfer Helmut, Hebebrand Johannes, Hinney Anke
Abstract excerpt
Studies in rodent models demonstrated that the central cannabinoid receptor (Cnr1) mediates the orexigenic effects of cannabinoids. To analyze whether genetic variation in the cannabinoid receptor gene (CNR1) is implicated in human obesity, we initially genotyped 8 single nucleotide polymorphisms (SNPs) located in the 5' region (rs9353527, rs754387, rs6454676), intron 2 (rs806379, rs1535255), exon 3 (),...