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The biosynthesis and biological function of diphthamide

23 Aug 2013

Abstract excerpt

Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified histidine residue, named diphthamide. Genetic and biochemical studies have revealed that diphthamide biosynthesis involves a multi-step pathway that is evolutionally conserved among lower and higher eukaryotes. During certain bacterial infections, diphthamide is specifically recognized by bacterial toxins, including...

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PMID: 23971743
DOI: 10.3109/10409238.2013.831023

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The biosynthesis and biological function of diphthamidePMID 23971743Read ↗

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