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Article

Insights into diphthamide, key diphtheria toxin effector.

Toxins - 3 May 2013

Abdel-Fattah Wael, Scheidt Viktor, Uthman Shanow, Stark Michael J R, Schaffrath Raffael

Abstract excerpt

Diphtheria toxin (DT) inhibits eukaryotic translation elongation factor 2 (eEF2) by ADP-ribosylation in a fashion that requires diphthamide, a modified histidine residue on eEF2. In budding yeast, diphthamide formation involves seven genes, DPH1-DPH7. In an effort to further study diphthamide synthesis and interrelation among the Dph proteins, we found, by expression in E. coli and co-immune precipitation in...

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Source

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Identifiers

PMID: 23645155
DOI: 10.3390/toxins5050958
PMCID: PMC3709272

Genes

DPH1
DPH5
DPH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insights into diphthamide, key diphtheria toxin effector.PMID 23645155Read ↗

The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network.Semantic proximity Read ↗

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The biosynthesis and biological function of diphthamideSemantic proximity Read ↗

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<em>DPH1 </em>Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2Semantic proximity Read ↗

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