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Article

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992

Parge H E, Hallewell R A, Tainer J A

Abstract excerpt

Superoxide dismutase enzymes protect aerobic organisms from oxygen-mediated free-radical damage. Crystallographic structures of recombinant human Cu,Zn superoxide dismutase have been determined, refined, and analyzed at 2.5 A resolution for wild-type and a designed thermostable double-mutant enzyme (Cys-6----Ala, Cys-111----Ser). The 10 subunits (five dimers) in the crystallographic asymmetric unit form an...

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Identifiers

PMID: 1463506
DOI: 10.1073/pnas.89.13.6109
PMCID: PMC49447

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