Article
Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992
Parge H E, Hallewell R A, Tainer J A
Abstract excerpt
Superoxide dismutase enzymes protect aerobic organisms from oxygen-mediated free-radical damage. Crystallographic structures of recombinant human Cu,Zn superoxide dismutase have been determined, refined, and analyzed at 2.5 A resolution for wild-type and a designed thermostable double-mutant enzy...
Topics
- Crystallography
- Hot Temperature
- Humans
- Hydrogen Bonding
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Recombinant Proteins
- Structure-Activity Relationship
- Superoxide Dismutase
- Tryptophan
- X-Ray Diffraction