Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice

Abstract excerpt

Loss of immune function and increased hematopoietic disease are among the most clinically significant consequences of aging. Hematopoietic stem cells (HSCs) from mice lacking aryl hydrocarbon receptor (AhR) have high rates of cell division. Studies were designed to test the hypothesis that aging AhR-null allele (AhR-KO) mice develop premature HSC exhaustion, and changes leading to hematological disease. Compared...

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