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Apicomplexan perforin-like proteins

1 Jan 2010

Abstract excerpt

Numerous perforin-like proteins are encoded in the genomes of apicomplexan parasites, where they are expressed in various life-cycle stages and play critical roles in pathogenesis and lifecycle progression. These ApiPLPs are characterized by the presence of a MACPF domain, responsible for pore-formation in target membranes in a number of systems, including many bacterial pathogens and effector cells of the immune...

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PMID: 20539776
DOI: 10.4161/cib.3.1.9794

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